KMID : 0545120000100020176
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Journal of Microbiology and Biotechnology 2000 Volume.10 No. 2 p.176 ~ p.180
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New Polyene Macrolide Antibiotics from Streptomyces sp.M90025
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Seo, Young Wan
Cho, Ki Woong/Lee, Hyi Seung/Yoon, Tae Mi/Shin, Jong Heon
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Abstract
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Three polyene macrolide antibiotics including two new compounds were isolated from the culture mycelia of a Streptomyces species. The structures of these metabolites were determined as elizabethin, a previously reported 28-membered macrolide and two analogs, using combined spectroscopic methods. These compounds exhibited antifungal activity and cytotoxicity against a human leukemia cell.
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